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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3690) Last page : ( 3696)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00653.8

Antitumor properties of novel 2-(1H-benzoimidazol-2-yland 2-benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitriles derivatives

Matiichuk Y. E.1,*, Chaban T. I.1, Ogurtsov V. V.1, Chaban I. G.2, Matiychuk V. S.3

1Department of General Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine

2Department of Pharmaceutical Chemistry FPGE, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine

3Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla Mefodia, Lviv, 79005, Ukraine

*Corresponding Author E-mail: v_matiychuk@ukr.net

Online published on 16 September, 2020.

Abstract

The synthesis and antitumor activity determination of some novel 2-(1H-benzoimidazol-2-yland 2-benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitrilesderivatives are described. By the reaction of 5-arylfurfurals with 1H-benzimidazol-2-yl) acetonitrile, benzthiazol-2-ylacetonitrile and (4-arylthiazol-2-yl)-acetonitrile were synthesed 3-(5-arylfuran-2-yl)acrylonitrile derivatives. The structure of synthesized compounds was confirmed by elemental analysis and 1H NMR spectroscopy. Within the framework of the International Research Program DTP (Developmental Therapeutic Program) of the National Cancer Institute's (NCI, Betezda, Merilend, USA) antitumor activity screening of synthesized compounds was carried out. It was established that these compounds are promising to search as anti-cancer agents.

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Keywords

Organic synthesis, Furan, Benzimidazole, Benzothiazole, Anticancer activity.

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