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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3671) Last page : ( 3674)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00649.6

A comparative study on the effectiveness of Iso-amyl cyanoacrylate tissue adhesive to silk sutures in the closure of periodontal flap: A split-mouth study

Dipika1, Sankari M1, Nambi Gopal2,*

1Dept of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, India

2Dept of Physical Therapy, College of Applied Medical Sciences, Prince Sattam Bin Abdul Aziz University, Al-Kharj, Saudia Arabia

*Corresponding Author E-mail: physio_gopal@rediffmail.com

Online published on 16 September, 2020.


Background: Many factors contribute to uneventful and healthy postoperative healing. Hence the primary union between flap margins during the closure of periodontal flap, post-surgery is of utmost importance. Isoamyl cyanoacrylate is a tissue adhesive, which can be used for the closure of elevated flaps to overcome the problems associated with conventional suture material like silk. Aim: This study aims to compare healing after periodontal flap surgery using isoamyl cyanoacrylate tissue adhesive and silk sutures. Materials and Methods: The split-mouth study was carried out on twenty patients who needed flap surgery for pocket therapy. The outcome measures measured were plaque index (PI), colony forming units (CFU), C-reactive protein levels pre and 1 week after flap surgery, wound healing index and VAS score for discomfort, aesthetics and ease of maintenance 1 week post-op. Paired t-test was used for intragroup post procedure improvement in each parameter, and independent sample t-test was used for intergroup comparison. Results: the cyanoacrylate group showed significant improvement in Plaque Index, colony forming units, C-reactive protein levels and VAS score for discomfort, aesthetics and ease of maintenance. Conclusion: Iso-amyl cyanoacrylate tissue adhesive is an effective procedure in periodontal flap surgery. Clinical Significance: Iso-amyl effectively reduces chair side time due to ease of application and shows better patient compliance due to minimal discomfort and better aesthetics when compared to conventional suture materials.



Periodontal flap surgery, Sutures, Cyanoacrylate tissue adhesive, Wound healing.


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