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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3587) Last page : ( 3592)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00634.4

New validated uv spectrophotometric methods for the determination of sparfloxacin in tablets

Sowjanya G.*, Sirisha Ch., Prasad M. Krishna

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Visakhapatnam-530045, Andhra Pradesh, India

*Corresponding Author E-mail: tatinenijishnu@gmail.com

Online published on 16 September, 2020.

Abstract

Two new, simple, economical, sensitive UV spectrophotometric methods (fundamental method (A) and area under curve (B)) have been developed for the quantitative estimation of sparfloxacin in bulk drug and pharmaceutical dosage forms. Sparfloxacin was estimated at 290 nm in phosphate buffer 6.8 and borate buffer 9.0. In method A and method B, the drug obeyed linearity in the range of 1–50μg/mL for both the buffers. The methods were tested and validated for various parameters according to ICH guidelines. The % RSD obtained in intraday, interday precision and robustness studies were found to be < 1.3 and the recovery of the drug was found to be 98.2 - 101.6% indicating the accuracy of the methods. The methods also proved to be sensitive as observed from the LOD and LOQ values. The proposed methods were successfully applied for the determination of sparfloxacin in tablets without any interference from excipients.

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Keywords

Sparfloxacin, Fundamental, Area under curve, Validation, ICH guidelines.

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