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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3536) Last page : ( 3544)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00626.5

Nanosponges-Revolutionary Approach: A Review

Prabhu Pavithra Pradeep, Mehta Chetan Hasmukh, Nayak Usha Y*

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India – 576104

*Corresponding Author E-mail: usha.nayak@manipal.edu

Online published on 10 August, 2020.

Abstract

Background

Nanotechnology-based drug delivery system is gaining tremendous importance in present era due to its potential to tackle a wide range of untouched challenges. One of the various nanoformulations formulated is nanosponges. Researchers have claimed these nanoformulations to be effective in the delivery of drugs having low water solubility. Enhancing water solubility has many advantages for particularly those drugs with a narrow therapeutic window. Also, these are even said to be effective in achieving targeted delivery, controlled delivery. Delivery of biologicals is likely to be made easy with this technology. Many non-pharmaceutical applications too were studied by scientists.

Objective

To understand the term ‘Nanosponge’, study its preparation, advantages, and applications.

Methods

A comprehensive study by the electronic search was undertaken to understand the term ‘Nanosponges’, its ways of preparation and itsbroader application in the pharmaceutical field. An effort was made to comprehend recent advancements and patents in the domainfrom the available resources.

Results

Various efforts have been put to formulate an ideal drug delivery system, nanosponge being one among them has been studied by researchers to show promising results.

Conclusion

One among the reasons for the failure of majority of drug therapy is ineffective formulation. Nanosponges have been formulated and studied to solve one such problem. Advantages dominate the countable number of drawbacks associated with this formulation. The molecular weight of the substance to be incorporated into the formulation is a critical parameter. However, this challenge is likely to be overcome by future researches.

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Keywords

Nanosponges, cyclodextrins, drug delivery, solubility enhancement and carrier.

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