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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3520) Last page : ( 3523)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00623.X

NSAIDs-Alendronate based Prodrug for Bone specific drug Targeting

Srivastava Ashish1,*, Mishra Ashutosh2, Rai A. K.1

1Department of Medicinal Chemistry, Institute of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Uttar Pradesh, India

2Acharya Narendra Dev College of Pharmacy, Babhnan, Gonda-271313, Uttar Pradesh, India

*Corresponding Author E-mail: srivastava457@gmail.com

Online published on 10 August, 2020.

Abstract

Objective

To evaluate the effect of diclofenac, indomethacin and ibuprofen conjugates on the bone.

Methods

A total of 120 Wistar female rats (aged 50 days, weight 100-150g) were administered intramuscularly with Dexamethasone disodium phosphate (7mg/kg of the body weight, once in a week) to induce the osteoporosis. At the end of the five weeks the rats were treated with Alendronate sodium (30mg/animal/day p.o.), and the prodrugs 1, 2, 3 at the dose of 25, 50 and 100mg/kg p.o. for 30 days

Results

The osteoporotic bone demonstrated the signs of improvement through various parameters like serum ALP, bone weight, length, diameter, bone ash, calcium, phosphorus and bone mineral density.

Conclusion

The results confirm that these prodrugs have the potential for the improvement of osteoporotic bones.

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Keywords

Bone mineral density, osteoporosis, serum alkaline phosphatase.

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