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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3494) Last page : ( 3500)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00619.8

Contemporaneous Novel Therapeutic Targets Recognized for their potential role in Colorectal, Lung, Breast, and Hepatocellular Carcinoma-A Review

Ghosh Abhinav Raj, Krishna K. L.*, Mehdi Seema, Nandini HS, Chandan HM, Bhooshitha AN

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India

*Corresponding Author E-mail: klkrishna@jssuni.edu.in

Online published on 10 August, 2020.

Abstract

Cancer chemotherapy is a complicated targeting approach due to the ability of cancer cells to undergo metastasis and differentiation. Several biomarkers have been identified for cancer therapy, they are of three main types namely predictive, prognostic, and diagnostic each with its characteristic to determine the condition of the patient. However, the full potential of novel targets for cancer therapy has not been comprehended and many obstacles remain, from the validation of novel targets to the design of specific agents, till evaluation of these agents in both preclinical and clinical settings. In maximizing the benefits of molecular therapeutics of cancer, it is necessary to have an understanding of the underlying molecular abnormalities and mechanisms involved. This review encompasses the current treatment approaches for Breast, Lung, Colorectal and Hepatocellular Carcinoma and the possible role of novel biomarkers which have been identified in the last five years and their respective transduction pathways, in the context of their potential as targets for cancer therapy.

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Keywords

Chemotherapy, metastasis, biomarkers, novel targets.

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