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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3351) Last page : ( 3355)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00595.8

Effect of Medicinal plants on amyloid β1–42 Intoxicated SH-SY5Y cell Lines -As Neuroprotective Evaluation

Karthika S.1,*, Kannappan N.2, Suriyaprakash TNK1

1Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Ponthavannam P.O, Perinthalmanna, Kerala-679325

2Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu-608002

*Corresponding Author E-mail: karthikaselvam1990@gmail.com.

Online published on 10 August, 2020.

Abstract

Amyloid-beta peptide (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder. The present study was designed to determine the effect of two medicinal plants used to treat neurodegenerative diseases on Amyloid beta intoxicated SHSY5Y cell line. Cytotoxicity of the different extracts of the two medicinal plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aβ, using the MTT assay. The n-Hexane extract of Hydrocotyle javanica (HJ) and Alcoholic extract of Peristrophe bicalyculata (PB) were the least toxic to the SH-SY5Ycells at the highest concentration tested (250μg/ml). All different extracts of two medicinal plants tested were observed to reduce the effects of Aβ-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression.

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Keywords

Amyloid-beta peptide (Aβ), Alzheimer's disease (AD), MTT assay, SHSY5Y cell line, Hydrocotyle javanicaPeristrophe bicalyculata..

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