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Anxiolytic potential of Perseaamericana M. by elevated plus maze test Fernandes Zeena, Khandige Prasanna Shama*, D'Souza Ullas Prakash Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Paneer, Derlakatte P.O, Mangaluru-574160, India *Corresponding Author E-mail: Prasannasham@nitte.edu.in
Online published on 10 August, 2020. Abstract The present study was undertaken to evaluate the anti-anxiety activity of the ethanolic and aqueous extract of Perseaamericana bark by the elevated plus maze method using swiss albino mice. The anti-anxiety activity of the ethanolic and aqueous extracts at doses 100, 200 and 400mg/kg body weight, was evaluated using the elevated plus maze method. Diazepam (0.5mg/kg) was used as the standard drug for comparison. In this study the ethanolic and the aqueous extract (200mg/kg and 400mg/kg) showed significant increase in the following parameters: % number of open arm entries and % time spent in open arms in Elevated Plus maze method. From the present study it can be concluded that Perseaamericana bark showed a significant anti-anxiety activity. Top Keywords Anti-anxiety activity, Perseaamericana, Diazepam, ethanolic and aqueous extract. Top | |
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