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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3289) Last page : ( 3292)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00583.1

An Experimental Study Evaluating the dose of oral D-Galactose on aging Induction in wistar albino male Rats

Sriram B. S.1, Ravichandra V.2,*, Holla Rajendra3, Moodithaya Shailaja4, Prasad Kishan5

1Research Scholar, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India

2Associate Professor, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India

3Professor and HOD, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India

4Additional Professor, Department of Physiology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India

5Professor, Department of Pathology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India

*Corresponding Author E-mail: ravi75chandra@yahoo.co.in

Online published on 10 August, 2020.

Abstract

Objective

The present study aimed to evaluate dose required for oral D-galactose in aging induction on Wistar albino male rats, by evaluating Cognitive, Biochemical and Histological variables. Methods Male Wistar albino rats were randomly separated into six groups (n=6). Group 1 (Control) received distilled water; Group 2 (Standard) received 120mg/kg subcutaneous (S.C) D -galactose; Group 3,4,5 and 6 received oral D-galactose in dose of 100, 120, 150 and 200mg/kg body weight respectively.

Results

Group 2 (120mg/kg) S.C and Group 3 (100mg/kg) orally administered D-galactose, showed increase in plasma MDA (Malondialdehyde) levels, appearance of lipofuscin pigment deposition in hepatocytes as well as increase in duration to find food along with total errors in Cognitive tests respectively compared to control. There is also significant decrease in plasma Glutathione levels in Group 3 compared to standard.

Conclusion

Oral D-galactose at dose of 100mg/kg can be employed as model for aging induction.

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Keywords

D-galactose, Radial maze, Heb William maze, Malondialdehyde (MDA), Glutathione (GSH), Lipofuscin.

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