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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3279) Last page : ( 3283)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00581.8

Cardioprotective activity of Lawsonia inermis roots against Doxorubicin Treated Mice

Divya B1, Shivashree S1, Mruthunjaya K.2, Manjula S. N.2,*

1Department of Pharmacology, JSS College of Pharmacy JSS Academy of Higher Education and Research, Mysore-570015, Karnataka, India

2Department of Pharmacognosy, JSS College of Pharmacy JSS Academy of Higher Education and Research, Mysore-570015, Karnataka, India

*Corresponding Author E-mail: snmanjula@jssuni.edu.in, Shivashree.shree@gmail.com

Online published on 10 August, 2020.

Abstract

Doxorubicin (DOX) is widely used in the treatment of various human neoplasms. The development of severe undesirable effects such as cardiotoxicity, myelotoxicity, GI Toxicity limits its therapeutic efficacy. The present study explores the beneficial effect of alcoholic extract of roots of Lawsonia inermis (LIALC) against doxorubicin induced cardiotoxicity and also to assess the antitumor efficacy of the combination treatment on tumor bearing mice. Cardiotoxicity was evaluated by measuring serum biomarkers glutamic oxalo transaminase (GOT), glutamic Pyruvic transaminase (GPT), alkaline phosphatase (ALP), creatinine and urea and cardiac antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and lipid peroxidation (LP) in heart homogenate. After treatment with extract for 2 weeks in doxorubicin intoxicated mice, the antitumor activity of combined treatment was determined by mean surviv time. Toxicity was evidenced by increased levels of serum biomarkers and decreased levels of cardiac antioxidant enzymes. Treatment with extract provided substantial protection by altering the above parameters to near normal level and prolonging the survival time of tumorous mice. However these results suggest that extract of roots of Lawsonia inermis has the ability to reduce cardiotoxicity and ameliorate doxorubicin antitumor effect.

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Keywords

Doxorubicin. Lawsonia inermis, Henna, cardiotoxicity, antioxidant.

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