Synthesis and Study Biological Activity of Gemcitabine Linked Heterocyclic Hybrids Mohammed Majed Jary1, Oleiwi Zeyad Kadhim2, Al-Hilo Muntadher Abdulabbas Hasan3, Mubarak Ahmed Kareem Hussein4, Obaid Ehab Kareem5, Radhi Ali Jabbar2,* 1College of Science, University of Kufa, Najaf, Iraq 2College of Pharmacy, University of Al-Kafeel, Najaf, Iraq 3College of Health and Medical Techniques, University of Al-Kafeel, Najaf, Iraq 4College of Pharmacy, University of Kufa, Najaf, Iraq 5College of Agriculture, Al-Qasim Green University, Babylon, Iraq *Corresponding Author E-mail: Alijebar56@gmail.com
Online published on 10 August, 2020. Abstract A series of 1,2,3-triazole and tetrazole derivatives have been synthesized by CuCl catalyzed cyclo addition reaction among 2-azido gemcitabine and compounds contain triple bond in their structure, alkyne and nitrile derivatives in DMF. The structures of the prepared compounds were analyzed by FTIR and 13C and 1H NMR spectroscopic techniques. The heterocyclic compounds screened against two types of bacteria are G-ve and G +ve bacteria, Escherichia coli, Staphylococcus aureus and Streptococcus pneumonia, using Azithromycin as control drug. Top Keywords Gemcitabine, 1, 2, 3-Triazole, Tetrazole and Antibacterial activity. Top |