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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3257) Last page : ( 3261)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00577.6

Synthesis and Study Biological Activity of Gemcitabine Linked Heterocyclic Hybrids

Mohammed Majed Jary1, Oleiwi Zeyad Kadhim2, Al-Hilo Muntadher Abdulabbas Hasan3, Mubarak Ahmed Kareem Hussein4, Obaid Ehab Kareem5, Radhi Ali Jabbar2,*

1College of Science, University of Kufa, Najaf, Iraq

2College of Pharmacy, University of Al-Kafeel, Najaf, Iraq

3College of Health and Medical Techniques, University of Al-Kafeel, Najaf, Iraq

4College of Pharmacy, University of Kufa, Najaf, Iraq

5College of Agriculture, Al-Qasim Green University, Babylon, Iraq

*Corresponding Author E-mail: Alijebar56@gmail.com

Online published on 10 August, 2020.

Abstract

A series of 1,2,3-triazole and tetrazole derivatives have been synthesized by CuCl catalyzed cyclo addition reaction among 2-azido gemcitabine and compounds contain triple bond in their structure, alkyne and nitrile derivatives in DMF. The structures of the prepared compounds were analyzed by FTIR and 13C and 1H NMR spectroscopic techniques. The heterocyclic compounds screened against two types of bacteria are G-ve and G +ve bacteria, Escherichia coli, Staphylococcus aureus and Streptococcus pneumonia, using Azithromycin as control drug.

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Keywords

Gemcitabine, 1, 2, 3-Triazole, Tetrazole and Antibacterial activity.

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