Preparation and Evaluation of Physical Characteristics of Vitamin E Nanoemulsion using virgin coconut Oil (VCO) and olive oil as oil phase with variation Concentration of tween 80 Surfactant Suryani1,*, Sahumena Muhamad Handoyo1, Mabilla Sry Yusti1, Ningsih Sri Rahmi1, Adjeng Andi Nafisah Tendri1, Aswan Muhammad1, Ruslin1, Yamin1, Nisa Michrun2 1Pharmacy Faculty, Halu Oleo University, Kendari-South East, Sulawesi, 93232 2Sekolah Tinggi Ilmu Farmasi Makassar, South Sulawesi *Corresponding Author E-mail: suryanisuere@gmail.com
Online published on 10 August, 2020. Abstract Vitamin E (alpha-tocopherol) has an anti-aging role and can protect the biologic membrane damage from free radicals. Vitamin E is highly lipophilic and has low stability, therefore to improve its effectiveness it is necessary to select appropriate carriers. Nanoemulsion is a drug delivery system in the form of aqueous oil dispersion stabilized by a combination of surfactants and co-surfactants that having droplet size 20–600 nm. Objective This research aimed to prepare and to evaluate the physical characteristics of vitamin E nanoemulsion. Preparation of vitamin E nanoemulsion using phase oil of VCO (Virgin Coconut Oil) and Olive Oil. Method The preparation of vitamin E nanoemulsion was performed by a combination of a low energy emulsification method with a magnetic stirrer and a method with high energy emulsification with a sonicator. The parameters of the nanoemulsion formula include organoleptic, pH, nanoemulsion type, percent transmittance, as well as the size and distribution of droplets. Results The results showed that the composition of the optimum formula of nanoemulsion vitamin E using VCO as oil phase consists of 2% VCO, 24% tween 80 and 6% PEG 400. The optimum formula was transparent, homogeneous, pH 6.19, nanoemulsion type of oil in water, transmittance percentage 98.7%, droplet size 11.9 nm, polydispersity index 0.023. The composition of the optimum formula of nanoemulsion vitamin E using olive as oil phase consists of 2% olive oil, 18–24% tween 80 and 6% PEG 400. The optimum formula was transparent, homogeneous, pH 6.46 and 6.29, nanoemulsion type of oil in water, transmittance percentage 100%, droplet size 13.2 nm and 10.4 nm, polydispersity index 0.004 and 0.034. Top Keywords Nanoemulsion, Vitamin E, VCO, Olive Oil, Tween 80. Top |