Synthesis, Characterization and Anti-oxidant Activity of some Novel Pyrazoline derivatives Basak Susmita, Bhat K Ishwar* Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka, India *Corresponding Author E-mail: bhatishwark@nitte.edu.in
Online published on 10 August, 2020. Abstract A series of novel phenylhydrazinylidene-pyrazoline (PZ1-PZ8) has been successfully synthesized from (1E,3E)-4-phenyl-1-(2-phenylhydrazinylidene) but-3-en-2-one derivatives by cyclization reaction using hydrazine hydrate in the presence of acetic acid and ethanol as an acid catalyst. All the compounds were characterized by Infrared spectroscopy and confirmed by 1H Nuclear Magnetic Resonance, Mass spectroscopy and elemental analysis. All the compounds have been screened for their antioxidant activity. Most of the compounds showed promising activity and can be used as a potential antioxidant drugs. 
Top Keywords Pyrazolines, 4-phenyl-(2-phenylhydrazinylidene) butanone, Anti-oxidant activity. Top |