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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3103) Last page : ( 3112)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00550.8

Serum level of Periostin Among Adult Asthmatic Patients

Al-Karkhy Mohammad A.1, Abdullah Shatha F.2,*, Nema Mustafa3

1Specialist Medical Doctor, Ministry of Health AL-Romady Teaching Hospital

2Assistant Professor, Dept. of Microbiology, College of Medicine, University of Baghdad

3Consultant in Respiratory Medicine, Dept. of Medicine, Baghdad Teaching Hospital, Baghdad College of Medicine

*Corresponding Author E-mail: shthabdullah@yahoo.com

Online published on 10 August, 2020.

Abstract

Periostin has emerged as a non invasive biomarker of asthma and allied with airway eosinophilia in asthmatics reflecting remodeling of airways tissue or fibrosis. A prospective case control study was involved Forty four (44) Iraqi asthmatic patients compared with 44 persons who apparently healthy age and sex matched as a control group. The (4) ml of Blood samples were aspirated from the study groups for the detection Periostin using ELISA. The serum level of periostin was increased significantly (median= 60.1ng/ml) among asthmatic group compare with (median = 25.7ng/ml) of control with the optimum cutoff level of serum periostin was 38.3ng/ml using ELISA. The optimum concentration of serum periostin cut off level for eosinophilic asthma endotype was 74.63ng/ml with a sensitivity and specificity of 81.3% and 85.7% respectively. The high Serum median concentration of Periostin showed a strong statistical significant association with poorly controlled asthmatic patients (118.1ng/ml) with P value= 0.0001. The median conc. of serum Periostin revealed a higher level in abnormal Eosinophil, monocytes and Total IgE (101.8ng/ml), (109.5ng/ml) and (65.94ng/ml) respectively than the median conc. of normal counts. The treatment that was taken by asthmatics had no significance correlation with serum concentration of Periostin. Thus measuring serum Periostin in asthmatics is crucial to predict disease susceptibility, severity and disease control as well as response to treatment.

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Keywords

Asthma, Periostin, Eosinophil, Asthma biomarkers, Asthma Control.

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