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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3093) Last page : ( 3097)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00548.X

Development and Validation of Analytical method for estimation of Mometasone furoate in Bulk and Pharmaceutical dosage form using U.V. Spectroscopy

Ravi Ayush1, Chatterjee Arindam1,*, Sharma Rahul1, Gaur Siddharth1, Shrivastava Birendra1, Kumar Parveen2

1School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India

2Department of Pharmaceutics, Shri Ram College of Pharmacy, Karnal, India

*Corresponding Author E-mail: chatterjee.arindam@hotmail.com

Online published on 10 August, 2020.


In the current work a UV-Visible spectroscopical technique having simplicity, sensitivity, rapidness, preciseness and accuracy has been developed and validated for quantification of Mometasone Furoate (MF) in bulk and pharmaceutical dosage forms. The guiding principle of the International Conference on Harmonization (ICH), were followed and the method has been validated for various analytical parameters like linearity, precision, and accuracy robustness, ruggedness, LOD, quantification limit and formulation analysis. The obtained results of the study were validated statistically. MF was detected at wavelength maxima of 246 nm in dichloromethane using spectrophotometer (double beam UV-Visible) and analysed in a concentration range from 1.0 to 10.0 μg/ml. The coefficient of correlation (r2) was observed 0.9993 and found in good agreement by Beer Lambert's law. The preciseness (intra-day and inter-day) was found compliant with the official RCD limits (RSD<2%). The recovery studies were performed to verify the accuracy of the projected methodology. The sensitivity of the strategy was assessed by decisive the limit of detection and limit of quantification. It had been concluded that the projected methodology for estimation of MF in active and in marketed formulation (cream) was easy, accurate, economical and precise. It is utilized with success within the quality control of dosage form and laboratory analysis.



Mometasone Furoate, Dichloromethane, UV-Visible spectroscopic method, Beer Lambert's law.


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