Formulation and Evaluation of Nano-fiber-based Transdermal patch of Cephalexin Choudhary Sidra1, Dharashivkar Sanket1, Mahajan Chetan2, Gaikwad Madhuri3 1Department of Pharmaceutics, Dr. L. H Hiranandani College of Pharmacy, Ulhasnagar 2Scientist-B, Wool Research Association, Thane 3Department of Pharmaceutics, AIKTC School of Pharmacy, Panvel *Corresponding Author E-mail: sidraeram@gmail.com
Online published on 4 July, 2020. Abstract In the present work polymeric nano-fiber patches were developed for the effective treatment of skin infection using cephalexin as model drugs. The nano-fibers were prepared by electro spinning technique by using polyvinyl alcohol (PVA) as a polymer and fibers were characterized on the basis of entrapment efficiency, fiber diameter, morphology, x-ray diffraction analysis, drug release behavior and in vitro antimicrobial test. The entrapment efficiency of the optimized formulation was 95%. The % cumulative release of drug from nano-fiber patch across the dialysis membrane was 96% at the end of 24h. The ex-vivo release of drug through nano-fiber patch across the goat skin was 81% at the end of 24 h. Top Keywords Cephalexin, Nanofiber, Electrospinning. Top |