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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2661) Last page : ( 2666)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00473.4

Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β-carbon

Basak Susmita, Bhat K Ishwar*

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka, India

*Corresponding Author E-mail: bhatishwark@nitte.edu.in

Online published on 4 July, 2020.


A series of (1E, 3E)-1-[2-(4-chlorophenyl)hydrazinylidene]-4-phenylbut-3-en-2-one(SC1-SC7) has been successfully synthesized from (1E)-1-(2-phenylhydrazinylidene) propan-2-one by condensation reaction in the presence of 20% NaOH as base catalyst. All the compounds were characterized by IR spectroscopy and confirmed by 1H NMR, Mass spectroscopy and elemental analysis. All the compounds have been screened for their antioxidant activity. Most of the compounds showed promising activity and can be used as a potential antioxidant drugs.



Hydrazone derivatives, Phenyl hydrazinylidene propan-2-one, Anti-oxidant activity.


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