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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2658) Last page : ( 2660)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00472.2

An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile

Chidrawar Anil B.1,*, Pokalwar Rajkumar U.1, Kaminwar Nitishkumar S.2

1P G Research Centre, Department of Chemistry, Degloor College, Degloor, S.R.T.M.U., Nanded, India – 431717

2P G Department of Chemistry, L. B. S. College, Dharmabad, S.R.T.M.U., Nanded, India-431717

*Corresponding Author E-mail: anilchidrawar74@gmail.com

Online published on 4 July, 2020.


A mixture of Bis methylthio methylene malononitrile (BMMM), thiourea and aniline/4-chloro aniline/4-methoxy aniline/4-nitro aniline on reflux with dimethyl formamide solvent in presence of K2CO3 for 5–6 hours. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature, washed with water gives 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile and its derivatives respectively. The synthesized compounds were characterized by elemental analysis and spectral data.



Bis methylthio methylene malononitrile, thiourea, 4-substituted anilines, K2CO3, dimethyl formamide.


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