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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2468) Last page : ( 2474)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00441.2

Expension in the field of Freeze-drying: An Advanced Review

Sandhya Mishra*, Disha Kesharwani

Department of Pharmaceutics, Columbia Institute of Pharmacy, Near Vidhan Sabha, Raipur, Chhattisgarh-493111

*Corresponding Author E-mail: sandhyamishra2911@gmail.com

Online published on 16 June, 2020.


As lyophilization technique exalts the efficiency of the product to a culminative point, it is important to understand the concept in detail as well as to gather the information about recent advancements related to it. This review aims at collecting all the information at one platform. Lyophilization/Freeze-drying process is an advanced drying method which is used now a days. This technique basically involves the sublimation process and is more efficient than normal drying process. This review mainly focus on cumulating the basics of lyophilisation(i.e. advantages, disadvantages, basic steps for lyophilzation, evaluation parameters) as well as the technical and instrumental advancements made to enhance the productivity of the process to multiple times. This review also includes recent advancements in pharmaceutical application of freeze-drying technique. It will be an effective tool for the researchers to select appropriate lyophilization technique for enhancement of their product's stability.



Lyophilization, Sublimation, Primary freezing, Desorption drying, bulking agent.


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