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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2427) Last page : ( 2434)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00435.7

Formulation and Evaluation of Clopidogrel Bisulphate Tablets by Liquisolid Compact Technique

Mahammed Nawaz1, Yadav Harshini1, Thulluru Ashok2, Narayana Narahari2, Saravanakumar2, Balaji Anna2, Mounika S.1,*

1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupati-517102, Andhra Pradesh India

2Centre for Pharmaceutical Research, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupati-517 102, Andhra Pradesh, India

*Corresponding Author E-mail: mounikamouni6390@gmail.com

Online published on 16 June, 2020.


In the present study an effort was made to improve dissolution profile of clopidogrel bisulphate by formulating into liquisolid (LS) compact. PEG400 was taken as non volatile solvent in preparation of LS compacts. compatibility of excipients and drug was confirmed by FT-IR studies. The prepared powder blend is having good flow properties. The entrapment of drug within the excipients was confirmed by SEM studies. Disintegration time of LS compacts was decreased by the incorporation of super disintegrants (sodium starch glycolate and pvpk30).F2 formulation was chosen as best formulation based on dissolution and disintegration profiles. The release profile of F2 LS was compared with marketed product (plavix) and results revealed that, the dissolution of drug in LS compact was higher when compared with marketed product, may be due to presence of drug in non-volatile solvent PEG400.



Clopidogrel bisulphate, liquisolid (LS), PEG400, disintegration, dissolution.


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