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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2246) Last page : ( 2250)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00404.7

Immunomodulatory and Antioxidant Activities of Phyllanthus niruri L. Extract against the Laying Hens Infected by Escherichia coli

Sabdoningrum Emy Koestanti1,*, Hidanah Sri1, Ansori Arif N. M.2, Fadholly Amaq2

1Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, East Java, Indonesia

2Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, East Java, Indonesia

*Corresponding Author E-mail: emykoestanti@yahoo.co.id

Online published on 16 June, 2020.


The purpose of this study was to determine the Phyllanthus niruri L. extract (PNE) as an immunomodulator and antioxidant in laying hens infected by Escherichia coli. This study used completely randomized design (CRD) with 20 chickens divided into six groups consisting of one negative control group given Na-CMC (P0-), positive control group given E. coli (P0+), and three test groups given the PNE 10% (P1), 20% (P2), and 30% (P3). Each test group was given a sample suspension orally by giving once a day for six consecutive days. At the age of 21 weeks E. coli was infected with concentration of 106 CFU/mL/body weight. After a week of the E. coli infection, PNE was given with various dosage for 4 weeks. We revealed the data of leukocytes, lymphocytes, SOD and MDA. The data were analyzed by analysis of variance and Duncan test. Interestingly, we showed that PNE at a dose of 10% can increase immune system and antioxidant activity. In sum, we conclude that PNE can increase immune system and antioxidant activity in laying hens infected with E. coli.



Antioxidant, Escherichia coli, immunomodulation, laying hen, Phyllanthus niruri L.


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