Nanoemulsion: Importance in Pharmaceutical Nanotechnology
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Nanoemulsions are transparent system mostly covering droplet size in nanometric scale because of their small droplet sizes. This review aims on the method of formulation, evaluation Methods, advantages and disadvantages and the different route of drug delivery of Nanoemulsion. Nanoemulsion is utilized as transdermal drug delivery and characterized as required component, which optimal isotropic and thermodynamically settled aqueous solute with droplet size generally in the size range from 10 to 200 nm. To improves the soluble and permeability of slightly water dissoluble drug. The in-vitro skin penetration profile of optimized manufacturing were compared with general drug formulation. The factors determines the transdermal penetration of medications are the movement of medication in solvent, discharge the medication solvent, also penetration of drug within skin These are enhancing the rate of absorption discharge volatility in absorption and enhance bioavailability. The methods used for the preparation of Nanoemulsions include high pressure homogenization, Microfluidization, ultrasonication, and spontaneous emulsification. The prepared Nanoemulsions are Characertized by in vitro drug release, Thermodynamical stability studies, Nanoemulsion Droplet size. The future direction on Nanoemulsion is to study the drug delivery of topical, parenteral, intravenous and other route of administration. In this review, the discussion is intended to give a basic knowledge about its preparation, evaluation, mechanism and its application.
Nanoemulsion, drug delivery, surfactants, applications, advantages, disadvantages.