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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1762) Last page : ( 1766)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00318.2

Evaluation of Anticonvulsant and Antioxidant Activity of Flacourtia indica on Pentylenetetrazole (PTZ) Induced Convulsions in Mice

Ayyanna C.*, Narmada B., Suresh G., Munaf D., Radha B., Bhavani K., Anitha M.

Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, India

*Corresponding Author E-mail: ayyannac5@gmail.com

Online published on 30 April, 2020.



To evaluation of anticonvulsant and antioxidant activity of Flacourtia indica on Pentylenetetrazole (PTZ) induced convulsions in mice


Present study animals are divided into 4 groups of albino mice (n=6) were used. The First group was received as control, second group as standard (diazepam, 4mg/kg); third to fifth groups were treated with ethanol extract Flacourtia indica (100, 200 and 400mg/kg). After 30 min of administration ethanolic extract of Flacourtia indica, in mice I. P injection of PTZ (75mg/kg). Anticonvulsant activity was determined by measuring the Latency, Jerky movements, Straub's tail, Clonic convulsions and Death/Recovery of animals in PTZ induced convulsions in mice.


In PTZ model, Flacourtia indica ethanolic extract at a dose of 400mg/kg prolonged latency and onset to seizure activity compared to 100 and 200 mg/kg.


Flacourtia indica possess anticonvulsant effect as they delay the latency of seizures produced by PTZ.



Flacourtia indica, Anticonvulsant, Anti-oxidant, Diazepam, Pentylenetetrazole.


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