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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1725) Last page : ( 1729)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00311.X

A New Spectrophotometric Method for the Micro Determination of Clopin-A with Bromo Cresol Green and its Application to Evaluate the Assay of the Drug

Prasanna I Lakshmi1,*, Naidu G. T.2, Fathima Nuzhath3, Huq G. Abdul4

1Department of Physics, Vignana Bharathi Institute of Technology, Hyderabad

2Department of Physics, Rayalaseema University, Kurnool

3Department of Sciences & Humanities, Al-Habeeb college of Engineering & Technology, Hyderabad

4Department of Chemistry, School of Sciences, Maulana Azad National Urdu University, Hyderabad

*Corresponding Author E-mail: prasannainguva@gmail.com

Online published on 30 April, 2020.


A simple, precise, versatile and a new spectrophotometric method is proposed for the estimation of microgram quantities of the drug Clopidogrel in the presence of Aspirin. It is also known as Clopin-A, The drug forms an Ion – pair complex with Bromo Cresol Green (BCG), the stoichiometry of which is established as 1:1 by Job's continuous variation method. The wavelength of the maximum absorbance of the Ion – pair complex is found to be 440nm. The absorbance values of the Ion – pair complex increased linearly with the increase in the amount of the drug Clopidogrel in the presence of Aspirin. This suggests the suitability of the method for the determination of the drug in the range 10μg/ml to 250μg/ml. This also indicates the verification of the Beer-Lambert's Law in this range. This method is successfully employed to evaluate the assay of commercial tablets in pharmaceutical formulations for Clopidogrel in the presence of Aspirin and the results agreed very well. The molar absorptivity and Sandell Sensitivity of the method are found to be 1.860×104 lit/mole/cm and 0.0225 μg/ml/cm2 respectively.



Spectrophotometry, Clopidogrel, Aspirin, Ion-Pair complex method, BCG, Pharmaceutical Formulations.


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