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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1453) Last page : ( 1456)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00265.6

Synthesis and Urease Inhibition Activity of 4-hydroxy-3-methoxy benzoic acid Derivatives

Sharma Priyanka, Parvinder, Kakkar Saloni*, Khatkar Anurag

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.

*Corresponding Author E-mail: salonikakkar2007@gmail.com

Online published on 22 April, 2020.

Abstract

A number of 4-hydroxy-3-methoxy benzoic acid (vanillic acid) compounds were prepared and evaluated for urease inhibition activity. All the prepared compounds were characterized by IR, 1H NMR spectroscopic techniques. Synthesized compounds were screened for Urease inhibition activity against jack bean urease by using indophenols method. Results exposed that compound 3, 14 and 17 with IC50 values of 33.52μg/ml, 32.41 μg/ml and 30.06μg/ml were the most active urease inhibitors comparable to standard thiourea (IC50: 33.50 μg/ml). Hence newly synthesized derivatives of vanillic acid derivatives exhibits considerable urease inhibition potency.

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Keywords

Vanillic acid, Synthesis, jack bean ureaseUrease inhibition, Indophenols method.

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