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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1447) Last page : ( 1452)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00264.4

Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide

Kadam Sagar*, Yadav Pradip, Landge Dhananjay

Hon. Shri. Babanrao Pachpute Vichardhara Trust's, Group of Institutions, College of Pharmacy, Kashti, Ahmednagar, Maharashtra, India

*Corresponding Author E-mail: sagarkadam1111@gmail.com

Online published on 22 April, 2020.

Abstract

In this study the formulation of safe and effective enteric coated matrix tablet of Loperamide was prepared for the effectual treatment of inflammatory bowel diseases. Direct compression method is used for the formulation of colon targeted matrix tablet of Loperamide. Eudragit FS 30 D polymer and Triethyl citrate this coating material is used for this tablet. This coated tablet evaluated for properties such as average weight, hardness and coat thickness. The In vitro release studies of prepared tablets was carried out for 100 rpm for first 2 hrs. Then replaced with 7.4 pH phosphate buffer and continued for 24 hrs. According to United States Pharmacopoeia (USP) limits, the percentage weight variation, percent friability and content of drug molecule for all the formulations are in the range of USP limits. From the results obtained, Loperamide would be a hopeful formulation to achieve the aim which cure inflammatory bowel diseases without any gastric irritation, which is helpful for patients having pre-history of ulcerative colitis.

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Keywords

In vitro dissolution, Loperamide, stability study, Eudragit FS 30 D, release kinetics.

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