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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1386) Last page : ( 1390)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00254.1

New Validated Analytical Methods for the Determination of Methenamine Hippurate (An Antibiotic Agent)

Naik Raghu Raj*, Deepti Choppala Asha, Prathyusha Sistla Mounica

Mukthinuthalapati Mathrusri Annapurna GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India

*Corresponding Author E-mail: rajraghu496@gmail.com

Online published on 22 April, 2020.


Methenamine hippurate is an antibiotic used for the treatment of urinary tract infections but no other types of bacterial infections (such as in the blood) or for viral infections (such as the common cold or flu). Methenamine hippurate acts as an antibiotic that stops the growth of bacteria in urine. Methenamine hippurate helps to make the urine acidic. When the urine is acidic, Methenamine hippurate turns into formaldehyde to kill the bacteria. Four new spectrophotometric methods have been proposed for the estimation of Methenamine hippurate in pharmaceutical formulations using acetate buffer (pH 2.4) and borate buffer (pH 9.0), phosphate buffer (pH 7.0) and phosphate buffer (pH 8.0). Methenamine hippurate has shown absorption maxima at 230 nm in all the methods. Methenamine hippurate obeys Beer-Lambert's law over the concentration range 10–80 μg/ml in all the methods and all the methods were validated as per ICH guidelines.



Methenamine hippurate, Spectroscopy, Acetate buffer, Phosphate buffer, Borate buffer, Validation.


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