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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1333) Last page : ( 1338)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00246.2

Antihaemorrhoid Activity of Isolated and Semi-Synthesized Rutin Derivative from Euphorbia hirta Linn

Kori Yashpal S*, Yogi Bhumika, Gupta Sujeet

Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education and Research, Lucknow-206020, (U.P.), India.

*Corresponding Author E-mail: Koriyashpal@gmail.com

Online published on 22 April, 2020.



The present study evaluates the anti hemorrhoid activity of the ethanolic extract, isolated rutin, and a new rutin derivative semi synthesized from Euphorbia hirta Linn.


Extraction using Soxhlet apparatus to obtain ethanolic extract from the whole plant of Euphorbia hirta Linn. followed by isolation of a vital Flavanoid (rutin), and synthesizing a new rutin derivative. The anti hemorrhoid activity was, evaluated by inducing hemorrhoid using croton oil preparation in Wistar Albino rats. The anti hemorrhoid potential was, determined by recto anal coefficient. The histopathological evaluation was done to evaluate the severity sore between treated and untreated groups.


Treatment of the rectoanal cell line for five days with isolated rutin (0.015 ± 0.0023) and semi synthesized drug (0.020 ± 0.0035 *) showed remarkable healing as compared to ethanolic extract 0.020 ± 0.0039 **.


The results indicate that Euphorbia hirta Linn could be useful as an anti-hemorrhoid drug, hence from this study, its concluded that ethanolic extract, isolated rutin, and semi-synthesized rutin derivative possess significant anti-hemorrhoid activity, complementary studies should be made to establish its use mainly in India. Further research on rutin for the discovery as a potent anti hemorrhoid agent is required, to synthesize a compound as a useful lead molecule with a better pharmacological profile.



Euphorbia hirta Linn. Isolation, Rutin, Semi-synthesized rutin derivative, Anti hemorrhoid activity.


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