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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1319) Last page : ( 1323)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00243.7

The effect of Nigella sativa and Eucheuma cottonii in Collagen-induced Arthritis mice

Saidin Khalimatun S.1, Jais Mohamad R.1, Ismail Elysha N.2, Ishak Reezal1,*

1Universiti Kuala Lumpur, Institute of Medical Science Technology, A1–1, Jln TKS 1, Taman Kajang Sentral, 43000, Kajang, Selangor, Malaysia

2Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia

*Corresponding Author E-mail: reezal@unikl.edu.my

Online published on 22 April, 2020.


Arthritis is a common autoimmune disease characterized by chronic inflammation at the synovial joint. Most treatments that are currently used have its own downside and give rise to natural plants as alternative remedy. This study investigates the effect of Nigella sativa and Eucheuma cottonii extracts in reducing inflammation and the severity in collagen-induced arthritis mice. The collagen-induced arthritis mice were fed with Nigella sativa and Eucheuma cottonii extracts for 21 days. The results were recorded from inflammation scoring and neutrophil infiltration in the knee joints. This study demonstrated that mice treated with Nigella sativa extract showed significant decrease (p<0.05) in inflammation scoring and the numbers of neutrophil infiltration as compared to other treated groups. Treatment with Eucheuma cottonii extract also demonstrated a significant decrease (p<0.05) in the inflammation scoring. The extract from Nigella sativa has evidently reduced the inflammation in collagen-induced arthritic mice and showed better results than Eucheuma cottonii treatment.



Nigella sativaEucheuma cottonii, Collagen-induced arthritis, Inflammation, Neutrophil.


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