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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1297) Last page : ( 1302)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00239.5

Syzygium cerasoideum concentrates lessen high-FAT eating routine Instigated Heftiness and Diabetes in C57BL/6 Mice

Sadik Shaik1,*, Geetha K.M.2, Vasia1

1Department of Pharmacology, Oxbridge College of Pharmacy, Bengaluru.

2Department of Pharmacology, Dayananda Sagar University, Bengaluru.

*Corresponding Author E-mail: shaikpharmacy@gmail.com

Online published on 22 April, 2020.

Abstract

Antiobesity and antidiabetic exercises of the concentrates of Syzygium cerasoideum were examined by considering the in-vivo impacts of HFD actuated heftiness in C57BL/6 mice and OGTT in Wistar rodents. The counter stoutness and against diabetic impacts of MESC and CESC on HFD incited heftiness in mice were explored for about a month. The oral glucose resilience test has frequently been utilized to assess evident insulin discharge and insulin opposition in different clinical settings. In the present examination, the oral glucose resilience test demonstrates a critical decrease in blood glucose levels of MESC 400mg/kg at 30min contrasted and typical control. The MESC and CESC extracts at various portions assessed against HFD-prompted diabetes/antiobesity in C57BL/6 mice, the results have exhibited that MESC 200 and 400mg/kg have antidiabetic property. The high-fat eating regimen nourished C57BL/6 mice demonstrated critical decrease of body loads on day 21 and 28, glucose and triglyceride levels toward the part of the bargain were factually noteworthy, *p˂0.05 when contrasted and the control, *p˂0.05 when contrasted and the HFD, shows antidiabetic and antiobesity action of the two concentrates. The MESC (200 and 400mg/kg) treatment lightened all these metabolic changes like body weight, blood glucose and hyperlipidemia that happened due to HFD.

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Keywords

Syzygium cerasoideum anti-obesity, Antidiabetic, High Fat Diet, C57BL/6.

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