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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1224) Last page : ( 1226)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00225.5

Synthesis and Antioxidnat activity of novel 2-Mercapto Pyrimidine Derivatives

Hussain M. Mumtaz Mohammed1,*, Bharthi D. R.2, Revanasiddappa B. C.3,**, Kumar Hemanth3,***

1Associate Professor, Department of Pharmaceutical Chemistry, SJM College of Pharmacy, JMIT Campus, Chitradurga.

2Professor, Department of Pharmacology, SJM College of Pharmacy, Chitradurga

3Associate Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangaluru

*Corresponding Author E-mail: mumtazmhussain@gmail.com,

**evergreen_revan@rediffmail.com,

***hemantkumar@nitte.edu.in

Online published on 22 April, 2020.

Abstract

A new series of 2-mercapto pyrimidines (3a-h) were synthesized by the reaction of thiourea with various substituted chalcones (2a-h) and were characterized by IR, 1H-NMR and Mass spectral analysis. The title compounds were tested for In-Vitro antioxidant activity, compounds 3c, 3e have exhibited promising antioxidant activity.

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Keywords

Chalcones, 2-mercapto pyrimidines, antioxidant activity, nitric oxide radical scavenging activity, superoxide anion scavenging activity.

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