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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1183) Last page : ( 1186)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00218.8

Hepatoprotective Activity of Leucas cephalotes against Paracetamol induced Hepatotoxicity in Rats

Islam G.1,*, Gahlot Kavita2, Mani Munesh1, Kumar Prevesh1, Shukla Divaker1

1Faculty of Pharmacy, IFTM University, Moradabad-244102, Uttar Pradesh, India

2School of Pharmaceutical Sciences, IFTM University

*Corresponding Author E-mail: gayyurul.islam@gmail.com

Online published on 22 April, 2020.

Abstract

The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Leucas cephalotes against Paracetamol induced liver damage in rats. The ethanolic extract of Leucas cephalotes (600mg/kg) was administered orally to the animals with hepatotoxicity induced by Paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution. The plant extract was effective in protecting the liver against the injury induced by Paracetamol in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the ethanolic extract of Leucas cephalotes possesses hepatoprotective activity against Paracetamol induced hepatotoxicity in rats.

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Keywords

Leucas cephalotes, Paracetamol, Hepatoprotective and Hepatotoxicity.

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