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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1167) Last page : ( 1170)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00214.0

Synthesis, Characterization and Anti-microbial Studies of (8E)-8-benzylidene-6-methoxy-4-phenyl-1, 4, 5, 6, 7, 8-hexahydro-2H-3, 1-benzoxazin-2-imine derivatives

Fathima Shabana, Kumar P. Bharath Rathna*

Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India

*Corresponding Author E-mail: bharathpharm@gmail.com,

Online published on 22 April, 2020.


A series of some new benzoxazines were synthesized and evaluated for antimicrobial activity. Benzoxazines are reported to possess a wide spectrum of biological properties such as anticancer, anti-microbial, antitubercular, antiplatelet, analgesic and anti-inflammatory activities. Regular clinical usage of anti-microbial drugs is allied with developing microbial resistance. Hence, the discovery of new safer antimicrobial drugs represents a demanding target for this research area. The reaction of 4-methoxy cyclohexanone with different aromatic aldehydes yield chalcones. 4-methoxy cyclohexanone was reacted with selected aromatic aldehydes which is an example for Claisen-Schmidt condensation. The title compounds were synthesized by treating chalcones with urea in presence of potassium hydroxide. Their structures were confirmed by IR, 1H-NMR and mass spectra. Anti-microbial activity was evaluated for the synthesized compounds. All synthesized compounds were evaluated for in vitro antibacterial activity and antifungal activity by cup plate method at 100μg/0.1 ml. Ampicillin and Amphoterician B were used as standard reference for comparing the antibacterial and antifungal activity respectively.



Synthesis, benzoxazines, chalcones, anti-microbial activity, Claisen-Schmidt condensation.


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