(3.236.65.63)
Users online: 2145    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 889) Last page : ( 894)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00168.7

The Genoprotective Activity of Aqueous Green Tea extract against Metronidazole and Tinidazole Genotoxic Effect

Kahtan Mahmood1, Hassan Ali Faris1, Al-Shawi Nada Naje1, Numan Intesar Tareq2, Bahader Ghaith Abbas3

1Pharmacology And Toxicology Department, College of Pharmacy, University of Baghdad, Baghdad, Iraq

2Pharmacology and Toxicology Department, College of Pharmacy, University of AL-Bayan, Baghdad, Iraq

3Pharmaceutical Chemistry Departments, College of Pharmacy, University of Baghdad, Baghdad, Iraq

*Corresponding Author E-mail: ali_1371982@yahoo.com

Online published on 9 April, 2020.

Abstract

Aim

The study designed to evaluate the Geno-protective effect of green tea extract against genotoxicity induced by metronidazole and tinidazole.

Methods

Thirty-six mice were used, For each experiment, The animals divided into 6 groups: Group I-Negative control administered distilled water; Group II-Healthy mice treated with metronidazole alone, Group III-Healthy mice treated with tinidazole alone; Group IV-Healthy mice administered green tea extract alone Group V-Healthy mice treated with metronidazole, followed by green tea extract administration, Group VI-Healthy mice treated with tinidazole, followed by administration of green tea extract.

Results

treatment with Tinidazole significantly increase total chromosomal aberration (0.185± 0.0039, 0.167±0.0049) as compared to negative control group (0.116±0.004, 0.103±0.004) in bone marrow and spleen cells respectively. In addition results showed significant change in total chromosomal aberration between the groups (II, IV, V) (0.122±0.012, 0.079±0.005, 0.101±0.0077) (0.121±0.005, 0.067±0.002, 0.087±0.004) in bone marrow cells and spleen cells respectively. In addition, the results shown that there are significant changes in total chromosomal aberration between the groups (III, IV, VI) (0.185±0.0039, 0.079±0.005, 0.133±0.0135) (0.167±0.0049, 0.067±0.002, 0.11±0.012) in bone marrow cells and spleen cells respectively.

Conclusion

Tinidazole has greater effect than metronidazole on total chromosomal aberration and the aqueous extract of green tea confers Geno-protective effect against the metronidazole or tinidazole induced genotoxicity in mice.

Top

Keywords

Genotoxicity, genoprotection, green tea, metronidazole, tinidazole.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
598,497,498 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.