Users online: 2394    [ij] [ij] [ij] 
Email id

Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 843) Last page : ( 849)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00159.6

Multivariate Calibration Technique for the Spectrophotometric Quantification of Rasagiline in Bulk drug and Pharmaceutical Formulations

Rani D. Naveena, Kokilambigai K. S.*, Lakshmi K. S.

Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Tamil Nadu, India

*Corresponding Author E-mail: kokilampharm@gmail.com

Online published on 9 April, 2020.


The study aims to establish an accurate, sensitive, simple and validated Ultra violet (UV) spectrophotometric technique using multilinear regression technique for the evaluation of Rasagiline in the bulk drug and pharmaceutical dosage form. Multivariate calibration technique is established on the basis of the linear regression equations by the use of correlation among the absorbance and concentration at five various wavelength. The λmax of Rasagiline was at 215 nm. The outcomes were treated statistically. A linear plot was obtained in the concentration range of 8–12 μg/mL and regression co-efficient was obtained to be 0.999. The percentage RSD for intraday and interday precision were observed to be 0.0409 and 0.0228 respectively. The percentage recovery was found to be in the range of 100.84–101.00% w/w.



Rasagiline, Antiparkinson agent, UV spectrophotometer, Multivariate calibration, ICH guidelines.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
597,297,993 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.