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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 843) Last page : ( 849)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00159.6

Multivariate Calibration Technique for the Spectrophotometric Quantification of Rasagiline in Bulk drug and Pharmaceutical Formulations

Rani D. Naveena, Kokilambigai K. S.*, Lakshmi K. S.

Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Tamil Nadu, India

*Corresponding Author E-mail: kokilampharm@gmail.com

Online published on 9 April, 2020.

Abstract

The study aims to establish an accurate, sensitive, simple and validated Ultra violet (UV) spectrophotometric technique using multilinear regression technique for the evaluation of Rasagiline in the bulk drug and pharmaceutical dosage form. Multivariate calibration technique is established on the basis of the linear regression equations by the use of correlation among the absorbance and concentration at five various wavelength. The λmax of Rasagiline was at 215 nm. The outcomes were treated statistically. A linear plot was obtained in the concentration range of 8–12 μg/mL and regression co-efficient was obtained to be 0.999. The percentage RSD for intraday and interday precision were observed to be 0.0409 and 0.0228 respectively. The percentage recovery was found to be in the range of 100.84–101.00% w/w.

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Keywords

Rasagiline, Antiparkinson agent, UV spectrophotometer, Multivariate calibration, ICH guidelines.

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