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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 819) Last page : ( 822)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00154.7

Association of Anti-mitochonderial antibody (AMA), Anti-soluble liver antigen (SLA) and HLA-DR3 in autoimmune hepatitis patients

Muslim Osamah Tahir1,*, Taher Abdulrazzaq Abaulla2

1Department of Internal Medicine, College of Medicine, University of Al-Qadisiyah, Iraq

2Al-Diwanyiah Teaching Hospital, Ministry of Health, Iraq

*Corresponding Author E-mail: osamahmuslim@gmail.com

Online published on 9 April, 2020.

Abstract

Background

Autoimmune hepatitis is a disease that is characterized by the inflammation of the liver. The reason for the appearance of this disease is still unknown. This disease is considered an autoimmune disease. HLA DR3 genes are associated with this disease and are analyzed by PCR technology.

Patients and Methods

Two groups of people were used for the study of AIH disease. The first group consisted of sixty Iraqi people. Nineteen males and forty-one females were there in this group. The average age of the individuals belonging to this group was 40.6. All of them were confirmed to have AIH disease after conducting several tests. There were fifty healthy individuals in the control group. There were fifteen males and thirty-five females in this group. All of them were Iraqi people having age ranging from 10 to 67 For the quantitative measurement of antibodies, ELISA tests were conducted. The grouping of infected patients was on the basis of age and sex.

Results

the results of the current study revealed that HLA is a condition characterized by the inflammation of the liver. The study showed a ROC value of 0.655 for this kind of autoantibody. Considering the HLA DR3 genotype, 58.3% of patients showed a positive relationship with OR value 7.35.

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Keywords

Autoimmune hepatitis, AMA, SLA, HLA-DR3, ELISA.

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