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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 727) Last page : ( 731)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00138.9

Application of Nanonization, Dimerization and Co-Solvency for Sterile Solution Formulations of Paracetamol

Bagul Sanyukta K.1,*, Singh Meera C.2

1S.K.N. College of Pharmacy, Kondhwa, Pune, 48, Maharashtra

2Professor, S.T.E.S's S.K.N. College of Pharmacy, Kondhwa, Pune, 48, Maharashtra, meerasingh2109@gmail.com

*Corresponding Author E-mail: sanyuktaghone@rediffmail.com

Online published on 9 April, 2020.



There was always need and demand to form paracetamol into aqueous injectable dosage forms to address the emergency needs of high fever conditions. The polyols like glycerine, though can dissolve paracetamol, are not parenterally tolerated in high concentration. Very recently in 1985 a break through happened when 1% paracetamol aqueous drip was introduced in the market. Now there are many such formulations in the market which are developed using various solubility enhancement techniques. Available patented methods and newer methods for paracetamol solubility enhancement were studied in this research in order to develop stable aqueous injection formulations of paracetamol.


To study, design and develop 1% aqueous injection of paracetamol as per patent and to reproduce it under laboratory conditions. To make use of Nanonization technique to make 1% Paracetamol drip formula as alternative to above formulation. To produce 150 mg/mL paracetamol small volume injection using co-solvency.


This research has made an attempt to study the 1% Paracetamol drip patent made by dimerization. This patented procedure was studied and reproduced under laboratory conditions. Nanonization as alternative to this patented procedure was successfully developed. 150 mg/mL paracetamol small volume injection using propylene glycol with nanonization was successfully developed.


Attempt was made to find different methods of solubility enhancement of paracetamol in order to get its newer products in LVP and SVP category.



Solubility enhancement, paracetamol aqueous solutions, dimer of paracetamol Co-solvency, Nanonization.


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