(18.207.136.189)
Users online: 2460    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 682) Last page : ( 686)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00131.6

Development and Evaluation of Pantoprazole Sodium Floating Gel

Solunke Rahul S1, Khade Ganesh A2,*, Krishnmurthy3, Deshmukh M T4, Shete R V.5, Kore K J5

1Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India

2Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India

3Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

4Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India

5Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

*Corresponding Author E-mail: gkhade738@gmail.com

Online published on 9 April, 2020.

Abstract

Objective

The current investigation is to development andevaluation of HPMC based floating oral In situ gel of Pantoprazole Sodium.

Method

Six formulations were formulate 2*3 factorial design.batch F-6 gives newer alternatives use of natural biodegradable polymer in situ gel formulation. Drug, Excipients and polymer compatibility studies were performed by FTIR and DSC.

Result

The formulation was optimized gelling capacity, drug contentrange 92.93±0.10%to 96.83±.0.15%.percentage yield is 64.00%, 75.93%, 87.83%,. 93.21% and 95.25% and 97.07% respectively. The consistency of all the formulations was in the range 5.0±0.1 to 7.1±0.1 mm. The consistency of all the formulations.the formulated gel The pH of all the formulations was found to be 6.5 ±1.0.viscosity 1.440, 1.500, 1.560, 3.708, 3.182, 4.000

Conclusion

It is to obtain the increased residence time and sustained drug release. The gel formed in situ afforded sustained drug release over 8 hrs periods. The formulations exhibited therapeutic efficacy.

Top

Keywords

Oral Floating gel, sustained Release, HPMC, Calcium Carbonate, Pantoprazole Sodium.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
597,940,723 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.