Development and Evaluation of Pantoprazole Sodium Floating Gel Solunke Rahul S1, Khade Ganesh A2,*, Krishnmurthy3, Deshmukh M T4, Shete R V.5, Kore K J5 1Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India 2Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India 3Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India 4Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India 5Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India *Corresponding Author E-mail: gkhade738@gmail.com
Online published on 9 April, 2020. Abstract Objective The current investigation is to development andevaluation of HPMC based floating oral In situ gel of Pantoprazole Sodium. Method Six formulations were formulate 2*3 factorial design.batch F-6 gives newer alternatives use of natural biodegradable polymer in situ gel formulation. Drug, Excipients and polymer compatibility studies were performed by FTIR and DSC. Result The formulation was optimized gelling capacity, drug contentrange 92.93±0.10%to 96.83±.0.15%.percentage yield is 64.00%, 75.93%, 87.83%,. 93.21% and 95.25% and 97.07% respectively. The consistency of all the formulations was in the range 5.0±0.1 to 7.1±0.1 mm. The consistency of all the formulations.the formulated gel The pH of all the formulations was found to be 6.5 ±1.0.viscosity 1.440, 1.500, 1.560, 3.708, 3.182, 4.000 Conclusion It is to obtain the increased residence time and sustained drug release. The gel formed in situ afforded sustained drug release over 8 hrs periods. The formulations exhibited therapeutic efficacy. Top Keywords Oral Floating gel, sustained Release, HPMC, Calcium Carbonate, Pantoprazole Sodium. Top |