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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 679) Last page : ( 681)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00130.4

The Effect of Oral Administration of Ipomoea batatas L. Leaves Etanolic Extract on Hematological Profile in Rats

Saputra Anak Agung Bagus Yoga1,2, Putra Dewa Gede Purnama1,2, Putra I Putu Yogi Astara1,2, Warditiani Ni Kadek1,*

1Department of Pharmacy, Mathematics and Natural Science Faculty, Udayana University, Indonesia

2Institute Forensic Science and Criminatology, Udayana University, Bali, Indonesia, 80361

*Corresponding Author E-mail: kadektia@unud.ac.id

Online published on 9 April, 2020.

Abstract

Sweet potato (Ipomoea batatas L.) leaves have been shown to have anti-diabetic, anti-inflammatory, anti-mutagenic, antioxidant, anticancer activities, wound healing. However, there is no research on the effect of ethanolic extract of I. batatas L. leaves on hematological profiles; hence, such research needs to be conducted. The study was carried out by administering a variety of dose of the ethanolic extract of I. batatas L. leaves from maceration results to several groups of rats during 28 days of treatment. Each group consisted of 7 rats with group distribution as follows: normal control (without treatment), negative control (given distilled water), treatment groups (group given extract at a dose of 10 mg/kg body weight, 100 mg/kg body weight, and 1000 mg/kg body weight). The results of an examination of rats ’hematological profiles showed that the group given the extract with 1000 mg/kg body weight dose had hemoglobin levels and number of red blood cells that significantly higher (P<0.05) compared to the other groups. Based on this, the ethanolic extract of I. batatas L. leaves have the potential to increase hemoglobin and erythrocyte levels.

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Keywords

I. batatas L. Ethanolic Extract, Hematological Profile, Rats.

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