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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 369) Last page : ( 344)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00122.5

Formulation and Development of Enteric Coated Tablet for Parkinson's Disease

Solunke Rahul S2, Dhawale Ravindra A1,*, kore K J.3, Deshmukh Madhuri T4, Rutuja R F5, Shete Rajkumar V6

1Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

2Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

3Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

4Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

5Dr Vitthalrao Vikhe Patil Foundation College of Pharmacy, villad ghat, Ahmednagar, 414111, Maharashtra, India

6Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India

*Corresponding Author E-mail: ravindradhawale01@gmail.com

Online published on 9 April, 2020.

Abstract

The current investigation is to formulate and develop enteric coated tablet of Ropinirole Hydrochloride. Enteric coated tablets were prepared by Wet Granulation method by using water as solvent. To protect drug from acid Eudragit L-100 was used as enteric coated polymer. Drug, Excipient and Polymer compatibility studies were performed by FTIR and DSC. The formulation was optimized with desirable Hardness, Friability and Disintegration time. Tablet exhibited Hardness between 5.1–5.8 Kg/Cm2, Friability 0.09–0.21%, Disintegration time 40–60 minutes and drug release between 78–95.56%. Optimized formula F4 showing the Friability 0.13%, Hardness 5.5 Kg/Cm2 and drug release 95.56%. Drug diffusion study was represented graphically.

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Keywords

Ropinirole Hydrochloride, Enteric coating, Eudragit L 100, Dopamine.

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