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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 6300) Last page : ( 6304)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01096.3

Development and evaluation of topical emulgel of aspirin using different polymeric bases

Khan Jiyauddin1*, Norfarhani Siti1, Sahu Ram K.3, Ruhi Sakina2, Kaleemullah Mohammed1, Al-Dhalli Samer1, Rasny Mohamed1, Budiasih Sri1, Baber Shariq1, Ng Chean Hui1, Shamiha Nik Nur1, Khan Gulam Muhammad4, Gamal O. E.5, Fattepur Santosh1, Nilugal Kiran1, Abdullah Ibrahim1, Asmani Fadli1, Yusuf Eddy1

1School of Pharmacy, Management and Science University, 40100 Shah Alam, Selangor, Malaysia.

2International Medical School, Management and Science University, 40100 Shah Alam, Selangor, Malaysia.

3Department of Pharmaceutical Sciences, Assam University, Silchar, Assam788011, India.

4School of Health and Allied Sciences, Pokhara University, Kaski, Nepal.

5Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, KSASaudi Arabia.

*Corresponding Author E-mail: jiyauddin_khan@msu.edu.my

Online published on 15 February, 2021.

Abstract

The purpose of the study was to prepare a stable Aspirin Emulgel. Carbopol 940 and Hydroxypropyl methyl cellulose (HPMC) were used as gelling agent which has good viscosity which makes them fairly popular for controlling the flow properties of topically applied dosage forms as they are inexpensive, transparent, harmless, east to wash and prepare. Oral Aspirin generate a gastrointestinal side effects such as ulceration, and perforation when Aspirin drug was taken orally. In this research, Acetylsalicylate acid was active ingredient, Carbopol and HPMC were gelling agent and distilled water as solvent. Emulsion contains Tween 80 and Span 80 was mixed into gel base. The finished formulation gives whitish colour for formulation using Carbopol, while transparent colour for formulation using HPMC. Stability studies were performed at different storage conditions; 2–4 oC (Cool room), 25 oC (Room temperature) and 40 oC (Oven) for 28 days to predict the stability of formulations. For formulation using Carbopol, there were no changes in color, stickiness, homogeneity, phase separation and centrifugation in formulation stored at 2–4 oC, 25 oC and 40 oC for 28 days. While for formulation using HPMC, there is no no changes in colour, stickiness, homogeneity, phase separation and centrifugation in formulation at 2–4 oC, and 25 oC but present of stickiness in formulation when kept at 40 oC for 28 days. Based on one-way ANOVA test at the 5% significance level that changes in pH values of sample was not significant at different level of time and temperature (p>0.05).

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Keywords

Aspirin, Carbopol 940, HPMC, Tween 80, Span 80, Emulgel.

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