Development and evaluation of topical emulgel of aspirin using different polymeric bases
*Corresponding Author E-mail: firstname.lastname@example.org
The purpose of the study was to prepare a stable Aspirin Emulgel. Carbopol 940 and Hydroxypropyl methyl cellulose (HPMC) were used as gelling agent which has good viscosity which makes them fairly popular for controlling the flow properties of topically applied dosage forms as they are inexpensive, transparent, harmless, east to wash and prepare. Oral Aspirin generate a gastrointestinal side effects such as ulceration, and perforation when Aspirin drug was taken orally. In this research, Acetylsalicylate acid was active ingredient, Carbopol and HPMC were gelling agent and distilled water as solvent. Emulsion contains Tween 80 and Span 80 was mixed into gel base. The finished formulation gives whitish colour for formulation using Carbopol, while transparent colour for formulation using HPMC. Stability studies were performed at different storage conditions; 2–4 oC (Cool room), 25 oC (Room temperature) and 40 oC (Oven) for 28 days to predict the stability of formulations. For formulation using Carbopol, there were no changes in color, stickiness, homogeneity, phase separation and centrifugation in formulation stored at 2–4 oC, 25 oC and 40 oC for 28 days. While for formulation using HPMC, there is no no changes in colour, stickiness, homogeneity, phase separation and centrifugation in formulation at 2–4 oC, and 25 oC but present of stickiness in formulation when kept at 40 oC for 28 days. Based on one-way ANOVA test at the 5% significance level that changes in pH values of sample was not significant at different level of time and temperature (p>0.05).
Aspirin, Carbopol 940, HPMC, Tween 80, Span 80, Emulgel.