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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 6295) Last page : ( 6299)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01095.1

Association of leptin in diabetes mellitus and obesity

Ambad Ranjit Dr.1*, Jha Roshan Kumar Mr.2, Chandi Dhruba Hari3, Hadke Saurabh Dr.4

1Associate Professor Department of BiochemistryDatta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, NagpurMaharashtraIndia.

2Tutor, Department of BiochemistryJawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), WardhaMaharashtraIndia.

3Assistant Professor Department of MicrobiologyJawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), WardhaMaharashtraIndia.

4Assistant Professor Department of MedicineDatta Meghe Medical College, Shalinitai Meghe Hospital and Research Centre, NagpurMaharashtraIndia.

*Corresponding Author E-mail: ambad.sawan@gmail.com

Online published on 15 February, 2021.

Abstract

INTRODUCTION: Diabetes mellitus is collectively a metabolic disorder and is characterised by long term hyperglycemia due to defect in insulin secretion, insulin action or by both of them. Type 2diabetes accounts approximately 90% of cases, it develops micro vascular and macro vascular complications which causes psychological and physical distress and puts a huge burden on the health care system and providers. Obese subjects generally persists high level of leptin which correlate with BMI and body fat percentage. Although correlation between BMI and leptin exists. In men, BMI was the variable which was most strongly correlated with leptin. AIM: This study was aimed to analyse in depth the latent role of leptin in a mechanism underlying obesity and type 2 diabetes mellitus. To this end, suggestive markers of type 2 diabetes mellitus and obesity were estimated in blood samples and its association with leptin was observed MATERIAL AND METHODS: The study was designed to be cross sectional observational study for the period of one year in tertiary care hospital in India. The study consisted of face to face questionnaire interviews, physical examinations, and laboratory analysis.200 Subjects were enrolled in present studies among them 50 of them were males and rest of 50 were females. And 100 controls were also included on the basis of inclusion and exclusion criteria. Anthropometric data were measured following standard protocols. Biochemical investigations were done following proper method for each parameter. RESULTS AND OBSERVATION: 64% of subjects were between the age group of 40–60 and mean age was 55.34 ± 2.43years. 56% of the total subject has BMI more than 30.leptin levels were elevated in the cases group as compared to controls and the differences were statistically significant (p<0.0001). CONCLUSION: Present study concludes serum leptin level was significantly elevated in patients with diabetes when compared to non-diabetics healthy control group.

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Keywords

Diabetes, Leptin, Obesity, CAD, Lipoproteins, BMI.

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