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Year : 2020, Volume : 13, Issue : 12
First page : ( 6212) Last page : ( 6217)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01083.5

Development and characterization of tadalafil solid dispersion using skimmed milk for improved the solubility and dissolution release profile

Shah Mansi1, Patel Dipti2*

1PhD Scholar, Parul Institute of Pharmacy and Research, Parul University, VadodaraGujaratIndia.

2HOD Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, VadodaraGujaratIndia.

*Corresponding Author E-mail: dipti.patel@paruluniversity.ac.in

Online published on 15 February, 2021.


Tadalafil has low solubility and low oral bioavailability, so it's a challenge to formulate suitable dosage form. In this Present investigation to enhance the dissolution rate and solubility skimmed milk is used as a carrier. Physical mixers were prepared using various drugs to carrier ratio. Material and Methods: Spry drying technology was used to prepared solid dispersion of drug with skimmed milk. Various techniques were used to characterize the solid dispersion immediately after they were made which includes Differential scanning calorimetry, fourier transform infrared spectroscopy, X-ray diffraction and in-vitro dissolution profiles. Results: The Differential Scanning Calorimetry thermograms of raw drug indicated of its anhydrous crystalline nature. In thermograms of solid dispersion, the characteristic peak was absent suggesting the change from crystalline nature to amorphous form. X-ray diffraction confirmed the results. The results of raw drug showed highly extreme peak characteristic of its crystalline nature where solid dispersion showed less intense, more diffused peak indicating the change in crystalline form. Fourier transform infrared spectroscopy studies indicated between drug and carrier there were no interaction. The whole formulation showed distinct enhancement in the drug release behavior and solubility. Conclusion: The optimum drug to carrier ratio 1:10 enhance the solubility and in-vitro drug release also increase by 3 fold. For improvement of drug release and solubility, it was concluded that as a carrier skimmed milk powder can be utilized very well.



Skimmed milk, Tadalafil, Solid dispersion, Solubility, Dissolution.


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