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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 6182) Last page : ( 6185)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01078.1

Docking investigation, synthesis and cytotoxic studies of coumarin substituted azetidinone derivatives

Deepika P.1, Dhanya P.1, Naseef P.P.2*

1Jamia Salafiya Pharmacy College, Pulikkal, Malappuram, Kerala, India.

2Moulana College of Pharmacy, Perinthalmanna, Malappuram, Kerala, India.

*Corresponding Author E-mail: drnaseefpp@gmail.com

Online published on 15 February, 2021.

Abstract

A new series of azetidin-2-one derivatives containing coumarin ring were designed and docked with the protein kinase C 0 receptor (1XJD), the docking scores obtained for certain derivatives are better than the natural ligand and the standard. The compounds which showed good docking scores were synthesized and characterized by spectral data. The cytotoxic activity of the synthesized compounds was tested by MTT assay and the compounds showed good activity on HeLa cell lines.

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Keywords

Anticancer, Docking, Azetidinone, Coumarin, HeLa cell, MTT.

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