Optimizing badam gum towards tableting excipients
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Background: Badam gum (BG), a plant exudate is obtained from Terminalia catappa. As BG is a novel polysaccharide, physico-chemical characterization was performed in order to establish its suitability as pharmaceutical excipient. Natural Polymers are economical, abundant, non-toxic and potentially Bio-degradable. Objective: To Characterize the Badam gum and to prepare and evaluate paracetamol tablet with different ratios of Badam gum. Method: Badam gum was prepared and subjected to biochemical tests (Molisch's, Benedicts and fehling's test) and preformulation studies. Direct Compression of paracetamol tablets using different ratios of Badam gum (0.06g, 0.12g, 0.24g, 0.36g, 0.48g, 0.6g, 0.72g, 0.84g) as disintegrant and MCC (5.94, 5.88, 5.76, 5.64, 5.52, 5.4, 5.28, 5.16) was carried out. Tablets were evaluated for Physicomechanical Properties, disintegration and dissolution. Results: Positive results obtained in the preliminary tests in the identification of Badam gum. Swelling Index was found to be 220%. DSC and FTIR Studies revealed that Badam gum is compatible with the drug. Hardness of formulation F5 was found to be 6 and other formulations was found to be 4. Disintegration time of F2 was found to be 90 Sec, whereas F6 disintegrated at 5 min 25 Sec. In in vitro dissolution studies, on comparing to all formulation, increasing the concentration of badam gum retards the faster release of Paracetamol. Conclusion: In this study, paracetamol tablets were prepared with different ratios of Badam gum. From the study it can be concluded that 2.5% of Badam gum can be used as disintegrant.
Badam gum, Disintegrant, Direct compression, Swelling index, Dissolution.