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Year : 2020, Volume : 13, Issue : 12
First page : ( 6170) Last page : ( 6175)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01076.8

Formulation and evaluation of chronomodulated drug delivery system of doxofylline for treatment of nocturnal asthma

Bichewar Shubhangi1*, Pillai Sujit Dr.1, Mandloi Rampal Singh1, Birla Nikhlesh1, Jain Sanket1

1GRY Institute of Pharmacy, Borawan (Distt. KhargoneIndia) 451228Madhya Pradesh.

*Corresponding Author E-mail: sanketj0960@gmail.com

Online published on 15 February, 2021.


Chronotherapeutic delivery system is required to be formulated to suit drug release conditions in various diseases like cardiovascular diseases, asthma etc. Asthma is disease of lung airways (bronchi) characterized by hyper active responsiveness to a variety of stimuli. Nocturnal asthma is condition where an exacerbation of the asthma is observed during the night times, such that worsening the functioning of the lung with increased airway response. Usually, asthma attacks are more predominant in early mornings so it is annoying for a patient to take medicine at late night, hence in this condition there is a demand for pulsatile drug delivery system which release the drug at required time at proper site with efficient therapeutic action. The main advantage of releasing the drug in required time in required quantity with satisfactory lag time. In the present study the doxofylline tablet was prepared by direct compression method and tablets were coated by dip coating method by using Sodium Starch Glycolate, Microcrystalline cellulose, Eudragit S100, Ethanol, Isopropyl alcohol, Dibutylpthalate. The tablets prepared were evaluated for various parameters like density parameters, thickness, hardness, friability, disintegration time, dissolution time. All parameters were found to be within limits. It was concluded that Formulation F6 was the ideal formulation with lag time of 6 hrs followed by burst release of drug.



Doxofylline, Microcrystalline cellulose, Sodium Starch Glycolate, Isopropyl alcohol, Eudragit (S-100).


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