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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 6022) Last page : ( 6026)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01050.1

Spectroscopic estimation of tamoxifen citrate using multilinear regression analysis

Ruban R.1, Manikandan K.1*, Lakshmi K S1

1Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and TechnologyKattankulathur-603203, Kanchipuram- District: Tamil Nadu, India.

*Corresponding Author E-mail: gurumani12@gmail.com

Online published on 15 February, 2021.

Abstract

A sensitive and exact UV spectroscopic technique with a multilinear regression technique for assurance of Tamoxifen citrate in the drug dosage form is developed. This technique relies on linear regression equations by utilizing the interconnection between absorbance and concentration at 5 selected wavelengths. The technique is precise, linear and accurate in the range of 20-120^g/mL. The numerical analysis with the multilinear regression method was utilized. The information procured for the evaluation of Tamoxifen citrate in bulk drug dosage form evidenced the high-level accuracy and precision after the multivariate analytical technique. Subsequently, this technique is extremely valuable with uncomplicated mathematical contents and is more dependable than the other spectroscopic techniques then it suggests an application in calibration models for routine analysis. The developed and validated method is useful for quantification of Tamoxifen citrate in Bulk and pharmaceutical formulation. The validation Parameters were as per ICH Guidelines.

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Keywords

Multilinear regression, Pharmaceutical analysis, Tamoxifen citrate, UV spectrophotometry Form.

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