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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 6009) Last page : ( 6016)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01048.3

Sinapic acid ameliorates acrylamide induced neurotoxicity through inhibition of oxidative stress in rats

Vineela Satuluri1*, Thakur Santh Rani2

1Assistant Professor, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India-522019.

2Division of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India-517502.

*Corresponding Author E-mail: vineela.cology@gmail.com

Online published on 15 February, 2021.

Abstract

Aim and Objective: In this study, we examined the possible protective effect of sinapic acid (SA) on acrylamide (ACR) induced neurotoxicity in both in-vitro and in-vivo models. Methods: U87MG cells were exposed to different concentrations of sinapic acid. After 24 hours, ACR was added to the cells and cell viability was measured through MTT assay. In in-vivo study, acrylamide administration (50 mg/kg bw, i.p. 3 times/week) for 4 weeks produced typical symptoms of neuropathy in rats. Rats were subjected to behavioral tests each week. Finally, after assessing behavior rats were sacrificed under light ether anesthesia and the excised SN was processed for biochemical analysis. Results: SA (30 mg/kg, for 4 weeks) significantly improved in neurological score and responses in a battery of behavioral tests. Sinapic acid markedly attenuated ACR-induced markers of oxidative stress viz., malondialdehyde (MDA) and improved the reduced glutathione (GSH) and superoxide dismutase (SOD) in sciatic nerve (SN). ACR reduced the cell viability in a concentration-dependent manner. Sinapic acid reversed ACR induced cytotoxicity. Conclusion: Our findings suggest the propensity of SA to attenuate ACR-induced neuropathy by attenuating oxidative stress.

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Keywords

Acrylamide, Neuropathy, Sinapic acid, Oxidative stress and Sciatic nerve.

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