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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5987) Last page : ( 5992)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01044.6

Preparation, standardisation and evaluation of hypoglycaemic effect of herbal formulation containing five ethnomedicinal plants in alloxan-induced hyperglycemic wistar rats

Sharma Archana1*, Pal Prosanta2, Sarkar Bapi Ray2, Mohanty J. P.1, Bhutia Sonam3

1Himalayan Pharmacy Institute, Majhitar, Sikkim University, East Sikkim-737136SikkimIndia.

2Department of Pharmaceutical Technology, University of North Bengal, West Bengal, India-734013.

3Government Pharmacy College, Government of Sikkim, Sikkim University, Sajong, Rumtek EastSikkim-737135India.

*Corresponding Author E-mail: sonamkzbhutia@gmail.com

Online published on 15 February, 2021.

Abstract

The present study was undertaken to evaluate the pharmacognostical parameters, formulation, standardization and hypoglycaemic effect of herbal preparation in alloxan induced diabetic rats. The physicochemical properties of polyherbal finished product were: Specific gravity (1.03 at 25°C), pH of 10%v/v solution (4.543), solid content (7% w/v), viscosity (4.59 cp), surface tension (43.37 dynes/cm) and refractive index (1.37). The colour (brown), odour (sweet aromatic), and taste (sweet) of polyherbal formulation was satisfactory in physical appearance. The study was also aimed to evaluate the antidiabetic activity of herbal formulation in alloxan induced diabetic rats model. The results of the body weight and blood glucose level of control, diabetic control group, standard group (Glibenclamide 5mg/kg)-standard drug used and two different doses of trial formulation (600mg and 300mg/kg)-summarised in Table No 1 and Table No 2 respectively. The initial body weight of Herbal formulation low dose and high dose were 123.33±5.78 and 185±8.38 respectively and after 11 days of treatment the bodyweight was decreased to 119.33±8.45 and1 70.33±7.79 respectively. Two different doses of the herbal formulation (low dose and high dose) i,e 123.33±5.78 and 185±8.38 blood glucose level were studied in two different groups of animals. Both groups showed a significant decrease of blood glucose level on alloxan induced diabetic rats when compared to control group. The low dose result shows for respective day 3: 5.01±0.21, day 7: 33.23±1.70 and day11: 63.20±2.46 and for high doses for day 3: 6.59±0.34, day 7: 35.26±1.84 and day 11: 65.63±2.46. Both groups showed a significant decrease of blood glucose level on alloxan induced diabetic rats when compared to control group. The present study showed that the investigation of the polyherbal formulation containing five herbs has a potent anti diabetic effect which could be used in the management of diabetes mellitus effectively.

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Keywords

Anti-hyperglycaemic, Herbal preparation, Ethno medicinal plants, Standardization, Alloxan-Induced anti-diabetic activity.

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