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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5947) Last page : ( 5952)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01038.0

Red Moringa oleifera leaf fermentation extract protecting hepatotoxicity in balb/c mice injected with Salmonella typhi through Nrf-2, HO-1, and SOD-2 signaling pathways

Riyaniarti M.M.1, Estri W.2, Widodo Nashi1, Widjajanto Edi3, Jatmiko Yoga Dwi1, Muhaimin Rifa'i1*

1Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia

2Department of Biology, Faculty of Sciences, Technology and Analitycal, Institut Ilmu Kesehatan Bhakti WiyataKediri, Indonesia.

3Departement of Medicine, Faculity of Medicine, Brawijaya University, MalangIndonesia.

*Corresponding Author E-mail: rifa123@ub.ac.id

Online published on 15 February, 2021.

Abstract

Oxidative stress can occur due to an imbalance between increased free radical production and a decrease in antioxidant capacity. Reactive Oxygen Species (ROS) excess will react with biological macromolecules either proteins or DNA and potentially damage hepatocytes. Nrf-2 activations can trigger the expression of anti-oxidative enzymes, such as HO-1 and SOD-2, which have important role in preventing inflammation. The purpose of this study was to look at the expressions of Nrf-2, HO-1, SOD-2, and histopathological features of Balb/C mice injected with Salmonella typhi after fermented extract administration of red Moringa oleifera. Data were analyzed by SPSS 22.0 ANOVA (p < 0.05) and followed by Duncan's Multiple Range Test. The results showed that fermented extract of red Moringa oleifera leaves could act as an immunomodulatory agent characterized by increased expressions of Nrf-2, HO-1, and SOD-2. Here, we also showed the histology improvement in Salmonella-injected mice after received fermented extract of red Moringa oleifera.

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Keywords

Nrf-2, HO-1, SOD-2, Necrosis, Immunomodulator, Moringa oleifera, Salmonella typhi.

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